A son of Texas, Ron Woodroof is an electrician and rodeo cowboy. In 1985, he is well into an unexamined existence with a devil-may-care lifestyle. Suddenly, Ron is blindsided by being diagnosed as H.I.V.-positive and given 30 days to live. Yet he will not, and does not, accept a death sentence. His crash course of research reveals a lack of approved treatments and medications in the U.S., so Ron crosses the border into Mexico. There, he learns about alternative treatments and begins smuggling them into the U.S., challenging the medical and scientific community including his concerned physician, Dr. Eve Saks. An outsider to the gay community, Ron finds an unlikely ally in fellow AIDS patient Rayon, a transsexual who shares Ron's lust for life. Rayon also shares Ron's entrepreneurial spirit: seeking to avoid government sanctions against selling non-approved medicines and supplements, they establish a "buyers club," where H.I.V.-positive people pay monthly dues for access to the newly acquired supplies. Deep in the heart of Texas, Ron's pioneering underground collective beats loud and strong. With a growing community of friends and clients, Ron fights for dignity, education, and acceptance. In the years following his diagnosis, the embattled Lone Star loner lives life to the fullest like never before.