5 Best Joint Supplements for Arthritis Pain & Knee Problems [2021]

As we get older, it sometimes feels like we experience more pain by the day. All pain is difficult to live with, but joint pain is particularly disheartening. Completing daily tasks or even moving can be excruciating.

So how do we combat this pain? Through medical advancements, expert scientists have identified the best natural ingredients to address this pain in an organic way and bring relief to millions of people.

So if you are plagued with chronic joint pain, don’t lose hope just yet​​—we might have a product that can relieve your symptoms. In this review, we review the best joint supplements on the market today. So just sit back, relax and let us do the heavy lifting.

Our Top Choices for The Best Joint Supplements

  1. ProJoint Plus - Overall Best Supplement for Joint Health
  2. Nuzena Joint Support - Effective Supplement for Joint Pain
  3. 1MD Nutrition - Popular Vitamins & Supplements for Osteoarthritis
  4. BioTrust Joint 33X - Most Trusted Supplement for Arthritis Pain Relief
  5. Phytage Labs Joint Relief 911 - Clinically Proven Joint Health Supplement

Here are our in-depth reviews of our top-rated joint health products:

#1. ProJoint Plus - Overall Best Supplement for Joint Health

ProJoint Plus makes supporting your joint health simple. Its high-quality ingredients impress users in the U.S. and across the world. VitaPost ProJoint Plus is a proprietary herbal extract blend that promotes joint health.

It has no harmful side effects and improves joint mobility and flexibility. Its all-natural blend of health ingredients may improve joint health without causing any negative side effects. It also aids in the body's healing process and overall wellness.

ProJoint Plus is made in an FDA-approved facility that meets GMP (Good Manufacturing Practice) criteria.


ProJoint Plus has been praised for its powerful, organic ingredients that target joint pain reduction and can even repair torn cartilage.

Giving your body the nourishment it requires is one of the best ways to keep your joints healthy. VitaPost ProJoint Plus is an excellent method to supplement your joint support nutrition.

The experts at ProJoint Plus recommend taking three capsules per day with a meal. For more intense cases of joint pain, users can take six capsules a day for the first two weeks as a loading dose. Always consult your healthcare provider for recommendations specific to your health conditions.

The brand offers a 30-day money-back guarantee so that you have a month to try the product and see if it works for you.

Ingredient List

  • Glucosamine Sulfate - This is a chemical that can be found in the fluid surrounding your joints. It is added to support joint health.
  • Chondroitin Sulfate - This is responsible for healthy cartilage resilience and suppleness.
  • Quercetin - An antioxidant that protects against free radicals and oxidants. It alleviates the tension that aging places on the joints.
  • Methionine - Amino acid that is high in antioxidants. It not only fights oxidants and free radicals, but also helps by combining the benefits of vitamins C and E.
  • Methylsulfonylmethane - Contains minerals and antioxidants that aid in the maintenance of healthy joints.
  • Bromelain - A protein-digesting enzyme that can be found in pineapples. It's a dietary supplement that promotes overall wellness.
  • Boswellia Extract - It is a herbal supplement that promotes joint health and has various other health advantages.
  • Turmeric - It has an antioxidant impact that promotes joint health and helps proactively prevent joint inflammation.


  • All-natural ingredients
  • Prevents joint degeneration
  • Maintains cartilage health
  • Provides energy throughout the day
  • Promotes healing and reduces inflammation
  • 30-day money-back guarantee


  • Only available online

Customer Experience

Thousands of people have given excellent feedback on how effectively this product works to get rid of persistent problems quickly. Through the use of ProJoint Plus, several people claim to have gotten rid of the arthritic symptoms that had been bothering them for years. This joint health supplement has a lot of great customer reviews from senior folks who have tried it.

⇒ Visit the Official Website of ProJoint Plus

#2. Nuzena Joint Support - Effective Supplement for Joint Pain

Nuzena was founded in response to a growing demand for unsurpassed quality, transparency, and education in the natural health industry. This natural supplement company is dedicated to helping people improve their health and wellness through an integrative approach.

Nuzena's mission is to help all of its customers accomplish their health goals by providing all-natural supplements produced from high-quality, clinically-backed components.

The company attempts to get to know each of its customers on a personal level. Through their free consultation, Nuzena offers a personalized approach to health that considers each person's nutrition, lifestyle choices, and specific health requirements.

Nuzena Joint Support is a natural joint supplement that can help you increase joint mobility and flexibility, relieve joint discomfort, and support your overall joint health in a safe and inexpensive method. It is manufactured in an FDA-approved facility that follows GMP requirements.


This well-researched, clean, and effective compound has been shown to aid joint cartilage regeneration through its use of Glucosamine and Chondroitin. It also aids in the reduction of moderate-to-severe joint pain, making it one of the best joint supplements on the market today.

Turmeric, Boswellia, Quercetin, and other natural anti-inflammatory compounds and antioxidants complement each other to help reduce the course of treating arthritis pain. Besides lowering inflammation and joint discomfort, they also support bone health and give a slew of other health benefits.

Nuzena recommends that you take two capsules once a day, around half an hour before a meal.

Ingredient List

  • Glucosamine Sulfate (1500mg) - Support joint health
  • Chondroitin Sulfate (150mg) - Promotes healthy cartilage
  • Turmeric Curcumin (150mg) - Antioxidant
  • Boswellia Extract (200mg) - Helps reduce pain
  • Quercetin (25mg) - Improves collagen synthesis
  • Bromelain (25mg) - Used to treat osteoarthritis symptoms
  • Methylsulfonylmethane/MSM (25mg) - Experts say that MSM works as a painkiller
  • Methionine (25mg) - Also used for pain relief in the joints


  • Non-GMO
  • Gluten-free
  • Small, easy-to-swallow capsules
  • Third-party tested
  • Brand offers a free consultation with a health specialist
  • Scientifically proven formula
  • Natural ingredients


  • Only available online
  • May not be compatible with certain medications

Customer Experience

Nuzena offers free U.S. shipping on all orders of $50 or more. For individuals that need their item quickly, they also provide a 2-day express shipping option via USPS.

Additionally, they use DHL International delivery for global shipments. Shipping times vary depending on the country's local delivery options. Nuzena has a 30-day return policy for items that are unused and in their original packaging.

Nuzena's Support Team can be reached via phone, email, or live chat on their website.

⇒ Visit the Official Website of Nuzena Joint Support

#3. 1MD Nutrition - Popular Vitamins & Supplements for Osteoarthritis

1MD Nutrition has established itself as a market leader in natural dietary supplements. Scale Media, a group of direct-to-consumer health, wellness, and nutrition brands, owns the company. Ben Flohr and Ziv Haklili founded Scale to empower brands that support people's health holistically.

1MD Nutrition sells supplements that are doctor-formulated, clinically tested, and designed with the health of customers in mind. Its natural-ingredient nutritional supplements are designed to help with a wide range of health issues and physical functions, including heart health, immune systems, and joint discomfort.

Cardiology, rheumatology, gastrointestinal, allergy & immunology, and urology are among the specialties represented within the 1MD team. The brand's supplements rely heavily on these fields. Through the strong fusion of advanced science and nature, its mission is to help people live longer, healthier lives.

All of 1MD's goods are created in the United States, and the company operates out of the Sherman Oaks neighborhood of Los Angeles, California.


1MD CurcuminMD Plus

1MD Nutrition’s CurcuminMD Plus supplements contain turmeric (curcumin), antioxidants, and other ingredients that help relieve joint discomfort. This product primarily improves joint health, but it also includes qualities that benefit heart health and cognitive function.

1MD’s CurcuminMD Plus contains curcumin that is 285 times more easily absorbed than most turmeric supplements. Boswellia Serrata derived from frankincense is another ingredient paired with curcumin for maximum results. The brand recommends taking one pill twice daily.

1MD KrillMD

1MD also offers a KrillMD omega-3 supplement. It's twice as potent as ordinary fish oil, without the awful aftertaste. The fatty acids EPA and DHA and the antioxidant astaxanthin, found in omega-3, contribute to joint and heart health and cognitive brain ability. Like CurcuminMD Plus, the brand recommends taking one pill of KrillMD twice daily.


  • All-natural ingredients
  • Formula made by doctors
  • Manufactured in the United States
  • Subscription options or a one-time purchase available


  • Users should consult their doctor before starting these supplements
  • Expensive

Customer Experience

The brand receives many positive customer reviews, both on its website and third-party sites. 1MD Nutrition guarantees the quality of its products, using only the best ingredients. So it comes as no surprise that the brand offers one of the most generous refund policies on the market. You have a whopping 90 days to get your money back if there are any issues with the product.

⇒ Visit the Official Website of 1MD Nutrition

#4. BioTrust Joint 33X™ - Most Trusted Supplement for Arthritis Pain Relief

BioTRUST's Joint 33X was created to supply customers with the nutrition they need to maintain their joint health while also relieving them of the physical stress of inflammation. Joint 33X is designed to get results in as little as five days with only one daily tablet.

The mixture uses proprietary substances that have never been combined in any other remedy to alleviate the pain that certain people experience with their joints. Dr. Jaime Hope designed this formula by using nutrients that specifically improve the function of joints while also protecting them from additional injury and lubricating them.

With Joint 33X, BioTrust has taken its game to the next level. This supplement is a proprietary combination of three specific ingredients for restoring, mending, and lubricating joints.


There are three patented chemicals that can be found in BioTrust’s Joint 33X: UC-II, AprèsFlex Boswellia extract, and Mobilee extract that make it stand out among other supplements.

UC-II 40mg

UC-II combats the loss of collagen. Collagen is essential for cartilage health, as it protects the joints when the bones move. UC-II acts differently from traditional collagen, which is now widely used and works by creating an "oral tolerance" process. In one study, UC-II was three times more effective than glucosamine and chondroitin to relieve joint pain and improve joint function.

Joints lose their lubrication as collagen decreases with age, thereby leading bones to grind together painfully.

AprèsFlex 100mg

ApresFlex is a potent extract derived from the Boswellia serrata tree, which produces a highly scented juice that has been valued for its health benefits since ancient times.

Enzymes that can break down collagen are already present in the body, but damaged joints are at a considerably higher risk. AprèsFlex enables people to provide their bodies with the enzyme protection they need.

The AprèsFlex has been extensively researched, with results suggesting that it can safely and efficiently relieve joint discomfort. According to the formula, customers just need the treatment for around a month to see a noticeable difference of a 20% reduction in their affliction.

Mobilee 40mg

Mobilee, the formula's final component, is a proprietary cure that contains hyaluronic acid and other substances to keep joints lubricated. At least ten studies have previously proven that the mixture is far more effective than hyaluronic acid alone.


  • Non-GMO
  • No artificial ingredients
  • Unique and patented components
  • Restores, preserves, and lubricates joints


  • Only available online
  • Effects can vary

Customer Experience

You don’t need a prescription to use Joint 33X, but you should consult with a doctor if you take any medication that it could possibly react with. One bottle is a month’s worth of dosages. You can reach customer support about any questions you may have via email. They are available 24/7. If there are any problems with the product, there is a 60-day money-back guarantee.

⇒ Visit the Official Website of BioTrust Joint 33X

#5. Phytage Labs Joint Relief 911 - Clinically Proven Joint Health Supplement

PhyTage Labs, a firm based in the United States, manufactures Joint Relief 911. The company makes a wide selection of supplements and products that are designed by a team of scientists and backed by research. The brand does this in order to give its customers a better quality of life and overall health.

The product works by targeting the source of joint inflammation and replenishing the synovial fluid that lubricates the joint. Synovial fluid is abundant in most twenty year old bodies, but it diminishes with age and use, resulting in greater rubbing of the bones and pain.

It's an entirely natural remedy that works with your body's natural mechanisms to restore mobility, restore young flexibility to your joints, and allow you to resume a pain-free lifestyle. It also helps customers regain flexibility in the finger joints, wrists, elbows, spine, back, neck, hips, toes, and just about any other joint area. The brand also claims to boost muscle strength and repair cartilage by causing new blood vessels to form in the muscles.


Joint Relief 911 is made from entirely natural ingredients, and its formula has been scientifically proven. The following are some of its ingredients:

Hyaluronic Acid

Hyaluronic acid is a common element in skin and health formulations because of its ability to increase the natural production of the beneficial synovial fluid, which promotes improved joint lubrication and cushioning. This ingredient is also known to help relieve joint discomfort by regulating inflammatory levels.

Andrographis Paniculata

Andrographis Paniculata, a popular Ayurvedic treatment, has been discovered to suppress a regulator of the body's inflammatory response. This reduces proinflammatory proteins as well as pain and redness-related cytokines. It has also been found that the substance helps with joint, brain, liver, and immunological function.


Silica is commonly used in health supplements and products because it aids in the formation of collagen protein and helps in the body's calcium absorption, both of which are necessary for the development of healthy and strong bones.

Magnesium Stearate

Magnesium stearate has been studied extensively and is known to help convert food into energy and deliver helpful nutrients across cell membranes. It was also discovered in several studies to aid in the maintenance of healthy bone structure and DNA.


  • Reduces joint pain and inflammation
  • Restores damaged cartilage
  • Scientifically tested
  • Natural ingredients


  • Only available online

Customer Experience

The majority of online reviews for Joint Relief 911 have been positive. Many reviewers commended the substance for providing joint relief and a general sense of well-being. Orders typically arrive within seven business days If you are dissatisfied with the product, the brand offers a 90-day return policy.

⇒ Visit the Official Website of Phytage Labs Joint Relief 911

What to Know When Looking for the Best Joint Supplements

Because we ingest supplements into our bodies, it is vital to know that a product is safe and uses high-quality ingredients. We have made a list of some of the top factors to consider when choosing a brand and product for joint health.

  • Reputation

The reputation of a brand can often signal the quality of the products they sell. You will want to make sure that you are buying from a company that has a good reputation and that is well known on the market for good and ethical business practices.

  • Ingredients

The ingredients are one of the most important things to consider when buying supplements. You will want to make sure that they are natural and not artificial. You should be looking for products with ingredients that have been extensively examined and shown to relieve pain and inflammation.

Glucosamine, MSM, and chondroitin are the three most common ingredients in joint health supplements. Other components such as hyaluronic acid and collagen are also regarded as vital because they help to improve joint strength directly. You should disregard any products with ingredients that appear unnecessary to the product's efficiency or are ranked lower.

  • Glucosamine

When it comes to joint supplements, it's difficult to know what you're looking at on the label. In fact, reading a label can make you feel as though you're reading a foreign language. Glucosamine sulfate is one ingredient you'll want to look for in your supplement. You should make sure that the supplement contains it.

Glucosamine, when taken orally, helps to strengthen connective tissue in your joints. When sulfate is added, the whole connective process can be completed. The process will come to a halt if sulfate is not present.

  • Compare Labels

You have to be ready to spend money. When it comes to pain management, you can not allow yourself to be cheap. After all, this is for the benefit of your health. Although some generic joint supplements may provide benefits, the majority of them are made up of inactive substances that will do you no good.

Compare the labels of new supplements before buying them; if the generic one has the same ingredients as the name brand one, go with the generic. If the name brand one, on the other hand, contains considerably more nutrients, you know it's worth the extra money.

  • Return and Shipping Policies

You'll need to know what to look for, and this is where your past buying expertise will come in handy. If the product is good, the manufacturer will not make the return process difficult for you, and you will receive your money quickly. If their product is poor and they know it, they will make the procedure as difficult as possible for customers to leave it.

  • Customer Reviews

Even if a product has the appropriate ingredients and appears to be in the correct dosage, you need to assess how customers feel about it. You have to look at the average customer experience and what products provided a positive overall experience.

Customer reviews will provide very useful information about everything there is to know about a product. Because they are written by people who have tried out the product, they speak from personal experience.

Frequently Asked Questions

Q1. What is a joint supplement?

Any supplement designed to strengthen and support the bones and cartilage in your joints is referred to as a joint supplement. These products are made to help with joint discomfort, inflammation, and swelling while also promoting joint mobility and strength.

Joint supplements, unlike prescription drugs, can be bought over the counter. These products are easily accessible online, or you may visit your local drugstore to find dozens of options.

Q2. What causes joint pain?

Joint pain can be triggered in a variety of ways. Being overweight or eating an improper diet might deprive the body of its nutrients to maintain healthy joints. Individuals with unhealthy inflammation or hormonal imbalances also may be more susceptible to joint discomfort than others. Furthermore, joint discomfort can be caused by overuse or misuse of the body when it moves in an incorrect manner.

Q3. Do joint supplements relieve joint pain?

Many substances in joint supplements have been shown in peer-reviewed research to help reduce pain and inflammation. Glucosamine, chondroitin, and MSM are the most researched compounds.

According to research, these supplements help reduce joint inflammation with reasonable consistency, especially in people with certain illnesses like arthritis. Joint supplements may even induce the growth of new collagen in injured joints, according to recent research.

Overall, joint supplements have a high level of reliability. People who suffer from joint discomfort have a strong probability of increasing their mobility and lowering joint pain after taking one.

Q4. How do joint supplements work?

Joint supplements should, on the whole, take a three-pronged approach to joint health. They should aid in reducing joint discomfort, the stimulation of cartilage repair, and the elimination of joint inflammation.

Essential substances that have been clinically evaluated to achieve these goals are included in the top-rated joint supplements. However, among the three objectives, it is critical that a joint supplement aids in the healing of damaged cartilage, as removing joint pain and inflammation is difficult without joint strengthening.

Some joint supplements include substances that promote cellular healing and boost joint lubrication. The grinding of bones surrounding the joints causes a lot of the discomfort associated with arthritis.

Lubricating the joints and encouraging cartilage regrowth can help prevent this grinding and significantly reduce pain. Collagen is sometimes added directly to joint supplements to help rebuild cartilage by increasing collagen availability.

Q5. What causes knee pain?

Knees, along with the legs, neck, and back, are the most common sources of discomfort. Knee aches can be caused by a variety of things, including short-term damage from incorrectly twisting your knee during activity.

This could also be an indication that high-impact sports, such as running on concrete are wearing down your joint cartilage over time. Knee pain can be caused by a variety of factors, including inactivity, carrying too much body weight, bad posture, inadequately managed injuries, and inadequate nutrition.

Q6. Are joint supplements safe?

Most of the common chemicals in joint supplements have been thoroughly researched. Chondroitin, MSM, hyaluronic acid, and glucosamine are all highly well-tolerated, with almost no side effects noted. Other lesser-known herbal extracts may have negative effects, but we observed no common side effects with components like turmeric and bromelain in our research.

In general, just stick to the instructions on the package and keep track of how you're feeling while using a joint supplement. If you notice something is bothering you, stop using it and consult your doctor to check if you have a condition that could be worsened by one of the chemicals in your joint supplement.

Q7. Can I take vitamins for my joints?

Some vitamins may be able to help support your joint health even more because inflammation causes arthritis and joint pain. The most important vitamins for joint health are strong anti-inflammatories and antioxidants. Vitamins such as vitamin C and vitamin E are important for joint health.

Although vitamin D is not technically an antioxidant, it is necessary for controlling your immune system's response to inflammation. Several significant studies have linked vitamin D levels to a lower incidence of arthritis. Although the direct link between the two is unknown, it appears to help halt the progression of arthritis.

Even if there isn't a significant correlation between vitamin D and joint health, it's still an excellent vitamin to take, especially during cold and flu season.


In conclusion, no one should live in pain when there are solutions that can drastically improve the quality of life one leads.

We know joint pain can be hard to live with. Your movement is limited, which can be frustrating. Supplements are a great way to deal with pain, and not only that, but they also, as we have seen, can help repair your joints.

However, choosing the right supplement for you can also be pretty frustrating. There are so many on the market that it can make your head spin. So, you can choose one from our list as we have made sure only to include the very best joint supplements available.

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